Sulopenem (CP-70429) is an orally active, parenteral penemantibioticwith broad-spectrum activities againstGram-positiveandGram-negative bacteria. Sulopenem has the potential for urinary tract infections and intra-abdominal infections treatment. Sulopenem is inactive againstPseudomonas aeruginosaandXanthomonas maltophilia^[1][2][3].

Sulopenem has the potential for uncomplicated and complicated urinary tract infections and intra-abdominal infections treatment, including multidrug-resistant (MDR) infections and infections attributable to quinolone-nonsusceptible and/or extended-spectrum β-lactamase (ESBL)-producing Gram-negative bacilli^[1].
Sulopenem inhibits the growth of most isolates of aerobic and anaerobic Gram-positive and Gram-negative bacteria, including methicillin-susceptibleStaphylococcus aureus,Streptococcus pneumoniae(penicillin-susceptible and -resistant isolates), group A and B β-hemolytic streptococci,Listeria monocytogenes,Enterobacteriaceae,Haemophilus influenzae, andMoraxella catarrhalisbut excludingP. aeruginosaandStenotrophomonas maltophilia, at a concentration of ≤1 μg/mL^[1].

The protective effects of Sulopenem in murine experimental systemic infections are superior to those of Imipenem/Cilastatin. In murine experimental mixed infection withEscherichia coliandBacteroides fragilis, Sulopenem has lower ED₅₀. In guinea pigs experimental lung infection withKlebsiella pneumoniae, Sulopenem is more effective than CZON or Cefotiam^[3].

349.45

Solid

C₁₂H₁₅NO₅S₃

120788-07-0

Room temperature in continental US; may vary elsewhere.

DMSO : 83.33 mg/mL(238.46 mM;Need ultrasonic)

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

• 1.

  请依序添加每种溶剂： 10% DMSO    90% (20%SBE-β-CDin saline)

  Solubility: ≥ 2.08 mg/mL (5.95 mM); Clear solution

  此方案可获得 ≥ 2.08 mg/mL (5.95 mM，饱和度未知) 的澄清溶液。

  以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

  将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明