L-Aspartic acid is is an amino acid, shown to be a suitable prodrug for colon-specific drug deliverly.

L-Aspartic acid is shown to be a suitable prodrug for colon-specific drug deliverly^[1]. L-[³H]Asp remaining in the brain at 5 min is increased by 206 and 178% by preadministration of 100 mM L-Aspartic acid and 100 mM L-Glu, respectively, whereas 100 mM D-Asp does not affect L-[³H]Asp efflux transport. That value for L-[³H]Glu at 20 min is increased by 145 and 156% by coadministration with 100 mM L-Aspartic acid and 100 mM L-Glu, respectively, but not by D-Asp. It is interesting that the apparent efflux rate of L-Aspartic acid across the BBB is sevenfold faster than that of L-Glu^[2].

133.10

Solid

C₄H₇NO₄

56-84-8

L-天门冬氨酸

• Amino acids

Room temperature in continental US; may vary elsewhere.

1M NaOH : 100 mg/mL(751.31 mM;ultrasonic and adjust pH to 12 with NaOH)

H₂O : 2 mg/mL(15.03 mM;ultrasonic and warming and heat to 60℃)

DMSO :< 1 mg/mL (ultrasonic;warming;heat to 80℃)(insoluble or slightly soluble)

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

• 1.

  请依序添加每种溶剂： PBS

  Solubility: 1 mg/mL (7.51 mM); Clear solution; Need ultrasonic and warming and heat to 60℃