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SU16f
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
SU16f图片
CAS NO:251356-45-3
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
50mg电议

产品介绍
SU16f 是有效的,选择性PDGFRβ抑制剂,对 PDGFRβ,PDGFR1,PDGFR2 的IC50分别为 10 nM,140 nM,2.29 μM。SU16f 抑制 PDGFRβ 受体从而可以阻断胃癌来源的间充质干细胞 (GC-MSC) 条件培养基在胃癌细胞增殖和迁移中的促进作用。
生物活性

SU16f is a potent and selectivePDGFRβinhibitor withIC50s of 10 nM, 140 nM, 2.29 μM forPDGFRβ, PDGFR1, PDGFR2, respectively[1]. Neutralization ofPDGFRβreceptor by SU16f blocks the promoting role of GC-MSCs (gastric cancer-derived mesenchymal stem cells) conditioned medium in gastriccancercell proliferation and migration[2].

IC50& Target[1]

PDGFRβ

10 nM (IC50)

PDGFR2

140 nM (IC50)

PDGFR1

2.29 μM (IC50)

体外研究
(In Vitro)

SU16f (20 μM; for 8 hours) pretreatment inhibits the promoting role of GC-MSC-CM in SGC-7901 cell proliferation[1].
SU16f (20 μM; for 8 hours) significantly abolishes PDGFRβ activation in SGC-7901 by GC-MSC-CM. SU16f pretreatment results in the upregulation of E-cadherin and downregulation of N-cadherin, Vimentin, and α-SMA. SU16f pretreatment leads to downregulation of p-AKT, Bcl-xl, and Bcl-2 levels and upregulation of Bax expression in SGC-7901 cells by GC-MSC-CM[1].

Cell Proliferation Assay[1]

Cell Line:SGC-7901 cells in GC-MSC/SGC-7901 co-culture system
Concentration:20 μM
Incubation Time:8 hours
Result:Inhibited the promoting role of GC-MSC-CM in SGC-7901 cell proliferation.

Western Blot Analysis[1]

Cell Line:SGC-7901 cells
Concentration:20 μM
Incubation Time:8 hours
Result:Significantly abolished PDGFRβ activation in SGC-7901 by GC-MSC-CM, and resulted in the upregulation of E-cadherin and downregulation of N-cadherin, Vimentin, and α-SMA.
分子量

386.44

性状

Solid

Formula

C24H22N2O3

CAS 号

251356-45-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder-20°C3 years
In solvent-80°C6 months
-20°C1 month
溶解性数据
In Vitro: 

DMSO : 50 mg/mL(129.39 mM;Need ultrasonic)

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM2.5877 mL12.9386 mL25.8772 mL
5 mM0.5175 mL2.5877 mL5.1754 mL
10 mM0.2588 mL1.2939 mL2.5877 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80℃, 6 months; -20℃, 1 month。-80℃ 储存时,请在 6 个月内使用,-20℃ 储存时,请在 1 个月内使用。