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Atezolizumab
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAS NO:1380723-44-3
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
50mg电议

产品名称
阿特珠单抗
MPDL3280A
产品介绍
Atezolizumab (MPDL3280A) 是一种人源化单克隆抗体 IgG1,抵抗程序性死亡因子配体1 (PD-L1),用于癌症研究。
生物活性

Atezolizumab (MPDL3280A) is a selective humanized monoclonalIgG1antibody against programmed death ligand 1 (PD-L1), used forcancerresearch.

体外研究
(In Vitro)

Atezolizumab (0, 2.5, 5, 10, 20, and 40 μg/ml; 24 hours; HOS and 143B cells) inhibits proliferation and induces immune-independent apoptosis of osteosarcoma cells[1].
Atezolizumab impairs the function of mitochondria to cause the imbalance between oxidants and antioxidants. Atezolizumab induces mitochondria-related apoptosis of osteosarcoma cells by activating JNK pathway. Atezolizumab (10 μg/ml; 24 hours; HOS and 143B cells) induces autophagy in osteosarcoma cells[1].

Clinical Trial
分子量

144590.50

性状

Liquid

CAS 号

1380723-44-3

中文名称

阿特珠单抗;阿替利珠单抗

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.