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Bevacizumab
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAS NO:216974-75-3
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
50mg电议
100mg电议

产品名称
贝伐珠单抗
Anti-Human VEGF, Humanized Antibody
产品介绍
Bevacizumab 是一种人源化的 IgG1 单克隆抗体,高亲和力且特异性地与所有VEGF-A结合。
生物活性

Bevacizumab, a humanizedIgG1monoclonal antibody, specifically binds to allVEGF-Aisoforms with high affinity.

IC50& Target

VEGF[1]

体外研究
(In Vitro)

Bevacizumab, a humanized monoclonal antibody, specifically binds to all VEGF-A isoforms with high affinity, and inhibits its interaction with VEGFR-1 and VEGFR-2[1]. Experimental analysis shows that the EC50of Bevacizumab to bind VEGF analyzed by ELISA is 0.18 μg/mL. Binding kinetics assays show similar results that Bevacizumab inhibits the VEGF-induced proliferation of HUVEC with an IC50value of 0.047±0.0081 μg/mL[2].

体内研究
(In Vivo)

It is demonstrated that the subconjunctival administration of FD006 and Bevacizumab can significantly inhibit CoNV in NaOH cauterized rats compared with the control group (p < 0.01)[2].

Clinical Trial
分子量

149 kDa(Average)

性状

Liquid

CAS 号

216974-75-3

中文名称

贝伐珠单抗

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.