Bevacizumab, a humanizedIgG1monoclonal antibody, specifically binds to allVEGF-Aisoforms with high affinity.

VEGF^[1]

Bevacizumab, a humanized monoclonal antibody, specifically binds to all VEGF-A isoforms with high affinity, and inhibits its interaction with VEGFR-1 and VEGFR-2^[1]. Experimental analysis shows that the EC₅₀of Bevacizumab to bind VEGF analyzed by ELISA is 0.18 μg/mL. Binding kinetics assays show similar results that Bevacizumab inhibits the VEGF-induced proliferation of HUVEC with an IC₅₀value of 0.047±0.0081 μg/mL^[2].

It is demonstrated that the subconjunctival administration of FD006 and Bevacizumab can significantly inhibit CoNV in NaOH cauterized rats compared with the control group (p < 0.01)^[2].

149 kDa(Average)

Liquid

216974-75-3

贝伐珠单抗

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