Cremophor EL, a polyoxyethylene castor oil derivative, is a nonionic surfactant. Cremophor EL is widely employed to improve dissolution and delivery of drugs^[1].

Cremophor EL is a widely used excipient. In the first 10 h, Cremophor EL at 5 mg/mL increases the impedance, then decreases it, and after 20 h of treatment, epithelial cell death is detected. Cremophor EL decreases cell viability and increases cell toxicity more than RH40. Both epithelial viability and monolayer integrity are seriously impaired at 10 to 50 mg/mL concentrations of Cremophor EL at 24-h treatment. Cremophor EL also enhances cell detachment^[1].

Viscous liquid

61791-12-6

聚氧乙烯蓖麻油EL

Room temperature in continental US; may vary elsewhere.

4°C, protect from light

Ethanol : 50 mg/mL(Need ultrasonic)

H₂O : 25 mg/mL(Need ultrasonic)