Corn oil 是从玉米胚芽中提取出来的一种油，可作为药物分子的载体。
| 生物活性 | Corn oil, extracted from the germ of corn, can be used as a carrier for drug molecules. |
体内研究
(In Vivo) | Corn oil-gavaged rats have 54% lower serum growth hormone (GH) levels, and replacement of GH into corn oil-gavaged rats by osmotic minipump infusion increase in situ MNCL cell proliferation to rates observed in water-gavaged animals[1].
Corn oil is commonly used as a feed additive or a delivery vehicle for lipophilic substances In an animal research setting[3].
Corn oil can become contaminated and cause death/systemic infections several days after IP injections, so corn oil should bealiquoted and frozen(recommendation); thaw and make fresh solution each time.
Corn oil is more recommended for gavage administration[4].
Intraperitoneal oil application causes local inflammation with depletion of resident peritoneal macrophages[5].
| Animal Model: | Female C57BL/6J mice (n = 90; age, 6 to 7 wk)[3] | | Dosage: | 0.1 mL. | | Administration: | Intraperitoneal injection every 48 h for a total of 4 injections over a 7-d period. | | Result: | At day 21, pharmaceutical-grade (PG) corn oil had a significantly higher pathology score compared with nonpharmaceutical-grade corn oil. No other significant differences between the corn oil groups were observed. The use of nonpharmaceutical grade corn oil did not result in adverse clinical consequences and is presumed safe to use for intraperitoneal injection in mice. |
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | | Pure form | -20°C | 3 years | | 4°C | 2 years |
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