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Ifenprodil hemitartrate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Ifenprodil hemitartrate图片
CAS NO:23210-58-4
包装:50mg
市场价:525元

产品介绍
艾芬地尔半酒石酸盐是一种典型的非竞争性 NMDA 受体拮抗剂。
Cas No.23210-58-4
别名酒石酸艾芬地尔
化学名4-((1R,2S)-2-(4-benzylpiperidin-1-yl)-1-hydroxypropyl)phenol hemi((2R,3R)-2,3-dihydroxysuccinate)
Canonical SMILESC[C@@](N1CCC(CC2=CC=CC=C2)CC1)([H])[C@@](O)([H])C3=CC=C(O)C=C3.C[C@@](N4CCC(CC5=CC=CC=C5)CC4)([H])[C@@](O)([H])C6=CC=C(O)C=C6.O[C@](C(O)=O)([H])[C@](O)([H])C(O)=O
分子式C21H27NO2.½C4H6O6
分子量400.49
溶解度DMF: 50 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml,PBS (pH 7.2): 1 mg/ml
储存条件Store at RT
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Ifenprodil is a selective antagonist of NMDA receptors that contain NR2B subunits (IC50 = 0.3 μM) and displays 150-fold weaker activity at those bearing NR2C or NR2D subunits.[1] Ifenprodil also acts as a potent ligand at receptors for σ1, emopamil binding proteins, and their σ-like, fungal counterpart ERG2 (Kis = 2, 5, and 1 nM).[2] This compound has been described as an α-adrenergic vasodilator, but is also reported to constrict cerebrovascular smooth muscle in vitro (EC50 = 2.4 μM).[3]

Reference:
[1]. Brauner-Osborne, H., Egebjerg, J., Nielsen, E.O., et al. Ligands for glutamate receptors: Design and therapeutic prospects J. Med. Chem. 43(14), 2609-2645 (2000).
[2]. Laggner, C., Schieferer, C., Fiechtner, B., et al. Discovery of high-affinity ligands of σ1 receptor, ERG2, and emopamil binding protein by pharmacophore modeling and virtual screening J. Med Chem. 48(15), 4754-4764 (2005).
[3]. Young, A.R., Bouloy, M., Boussard, J.F., et al. Direct vascular effects of agents used in the pharmacotherapy of cerebrovascular disease on isolated cerebral vessels Journal of Cerebral Blood Flow and Metabolism 1(1), 117-128 (1981).