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L-701,324
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
L-701,324图片
CAS NO:142326-59-8
包装与价格:
包装价格(元)
10mg电议
50mg电议

产品介绍
L-701,324 是一种有效的口服活性 NMDA 受体拮抗剂,通过阻断其甘氨酸 B 结合位点来拮抗 NMDA 受体的活性。
Cas No.142326-59-8
别名7-氯-4-羟基-3-(3-苯氧基)苯基-2(1H)-喹啉
化学名7-chloro-4-hydroxy-3-(3-phenoxyphenyl)quinolin-2(1H)-one
Canonical SMILESClC1=CC=C2C(NC(C(C3=CC=CC(OC4=CC=CC=C4)=C3)=C2O)=O)=C1
分子式C21H14ClNO3
分子量363.8
溶解度DMF: 30 mg/ml,DMF:PBS (pH 7.2) (1:2): 0.33 mg/ml,DMSO: 15 mg/ml
储存条件Store at RT
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

L-701324 is an orally active and long acting anticonvulsant with high affinity and selectivity for the glycine site on the NMDA receptor.Target: NMDA ReceptorL-701324 is a potent, active anticonvulsant with a reduced propensity to activate mesolimbic dopaminergic systems in rodents. L-701324 exhibits a beneficial action in the animal model of parkinsonian rigidity, but not that of parkinsonian akinesia. L-701324 (2.5-40 mg/kg, i.p.) dose-dependently decreased the muscle tone enhanced by haloperidol (1-5 mg/kg, i.p.).

References:
[1]. Piotr Wlaz, et al. Differential effects of glycine on the anticonvulsant activity of D-cycloserine and L-701,324 in mice. Pharmacological Reports 2011,63,1231-1234