| CAS NO: | 123690-79-9 |
| 包装 | 价格(元) |
| 10mg | 电议 |
| 50mg | 电议 |
| Cas No. | 123690-79-9 |
| 别名 | (3-氨丙基)(二乙氧基甲基)膦酸水合物 |
| 化学名 | (S)-(3-aminopropyl)(diethoxymethyl)phosphinic acid |
| Canonical SMILES | O[P@@](CCCN)(C(OCC)OCC)=O |
| 分子式 | C8H20NO4P |
| 分子量 | 225.22 |
| 溶解度 | DMSO: 0.1 mg/ml,Ethanol: 30 mg/ml,PBS (pH 7.2): 10 mg/ml |
| 储存条件 | Store at RT |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | CGP 35348 is a selective antagonist of γ-aminobutyric acidB (GABAB) receptor with IC50 value of 34 μM [1]. The GABAB receptor is a metabotropic transmembrane receptors for GABA that is linked via G-protein to potassium channel. It stimulates the opening of K+ channel and hyperpolarize the neuron. CGP 35348 is a selective GABAB receptor antagonist that can penetrate the blood-brain barrier. In rat cortex slices, CGP 35348 inhibited the potentiating effect of L-baclofen on adenylate cyclase stimulated by noradrenaline. In the hippocampal slice, CGP 35348 (10, 30, 100 μM) inhibited membrane hyperpolarization induced by L-baclofen (10 μM) and the inhibitory postsynaptic potential [1]. In the spinal cord of the rat, CGP 35348 (3-30 μg) inhibited L-baclofen-induced antinociception in a dose-dependent way [2]. In the rat, CGP 35348 induced pain-like response to mechanical stimulation in a dose-dependent way and reduced the paw withdrawal threshold to pressure [3]. In rats, CGP 35348(500 mg/kg) significantly reduced food consumption by the blockade of central GABAB receptors [4]. References: |
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