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Loreclezole
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Loreclezole图片
CAS NO:117857-45-1
包装与价格：
包装价格(元)
hydrochloride 10mg电议
hydrochloride 50mg电议

产品介绍
Loreclezole 是一种抗癫痫化合物，是一种选择性 GABAA 受体调节剂，可作为含有 β2 或 β3 亚基的受体的正变构调节剂。
Cas No.117857-45-1
别名氯瑞唑,R 72063
化学名(E)-1-(2-chloro-2-(2,4-dichlorophenyl)vinyl)-1H-1,2,4-triazole hydrochloride
Canonical SMILESCl/C(C(C(Cl)=C1)=CC=C1Cl)=C/N2N=CN=C2.Cl
分子式C10H6Cl3N3
分子量274.53
溶解度<1.37mg/ml in DMSO;<1.37mg/ml in ethanol
储存条件Desiccate at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Loreclezole, an antiepileptic compound, is a selective GABAA receptor modulator and acts as a positive allosteric modulator of β2 or β3-subunit containing receptors[1][2].

References:
[1]. Wingrove PB, et al. The modulatory action of loreclezole at the gamma-aminobutyric acid type A receptor is determined by a single amino acid in the beta 2 and beta 3 subunit. Proc Natl Acad Sci U S A. 1994 May 10;91(10):4569-73.
[2]. Sanna E, et al. Direct activation of GABAA receptors by loreclezole, an anticonvulsant drug with selectivity for the beta-subunit. Neuropharmacology. 1996;35(12):1753-60.