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DL-threo-PDMP(hydrochloride)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
DL-threo-PDMP(hydrochloride)图片
CAS NO:80938-69-8
包装与价格:
包装价格(元)
10mg电议
50mg电议
100mg电议

产品介绍
Cas No.80938-69-8
Canonical SMILESCCCCCCCCCC(N([H])[C@H]([C@@H](O)C1=CC=CC=C1)CN2CCOCC2)=O.Cl
分子式C23H38N2O3•HCl
分子量427
溶解度DMF: 25 mg/ml,DMSO: 30 mg/ml,Ethanol: 50 mg/ml,Ethanol:PBS (pH 7.2)(1:5): .05 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

DL-threo PDMP is a mixture of ceramide analogs that contains two of the four possible stereoisomers of PDMP : D-threo (1R,2R) and L-threo (1S,2S) PDMP. DL-threo-PDMP inhibits glucosylceramide synthase by 33 and 48% in MDCK cell homogenates when used at concentrations of 5 and 10 µM. It reduces the synthesis of glucosylceramide, increases cellular ceramide, and induces cell cycle arrest in vitro. The ability to inhibit glucosylceramide synthase has been found to reside in the D-threo (1R,2R) enantiomer. The D-threo PDMP enantiomer is also responsible for inhibition of β-1,4-galactosyltransferase 6 and prevention of lactosylceramide synthesis, which is a promotor of neuroinflammation in mice during chronic experimental autoimmune encephalomyelitis (EAE), a model of multiple sclerosis. DL-threo-PDMP increases amyloid-β (1-42) (Aβ42) and Aβ39 production independent of ceramide metabolism via modulation of γ-secretase activity in HEK293 cells expressing the γ-secretase substrate SC100.