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Galanin(rat,mouse)(trifluoroacetate salt)
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
包装:1mg
市场价:2192元

产品介绍
别名GAL (rat, mouse)
化学名glycyl-L-tryptophyl-L-threonyl-L-leucyl-L-asparaginyl-L-seryl-L-alanylglycyl-L-tyrosyl-L-leucyl-L-leucylglycyl-L-prolyl-L-histidyl-L-alanyl-L-isoleucyl-L-α-aspartyl-L-asparaginyl-L-histidyl-L-arginyl-L-seryl-L-phenylalanyl-L-seryl-L-α-aspartyl-L-lysyl-L-histidylglycyl-L-leucyl-L-threoninamide, 2,2,2-trifluoroacetate
Canonical SMILESNC([C@@]([C@@H](C)O)([H])NC([C@H](CC(C)C)NC(CNC([C@@H](NC([C@H](CCCCN)NC([C@@H](NC([C@H](CO)NC([C@@H](NC([C@H](CO)NC([C@H](CCCNC(N)=N)NC([C@@H](NC([C@H](CC(N)=O)NC([C@@H](NC([C@@]([C@H](CC)C)([H])NC([C@@H](NC([C@@H](NC([C@@H]1CCCN1C(CNC([C@H](CC(C)C)NC([C@H](CC(C)C)NC([C@@H](NC(CNC([C@@H](NC([C@H](CO)NC([C@H](CC(N)=O)NC([C@H](CC(C)C)NC([C@@]([C@@H](C)O)([H])NC([C@@H](NC(CN[H])=O)CC2=CNC3=C2C=CC=C3)=O)=O)=O)=O)=O)C)=O)=O)CC4=CC=C(O)C=C4)=O)=O)=O)=O)=O)CC5=CN=CN5)=O)C)=O)=O)CC(O)=O)=O)=O)CC6=CN=CN6)=O)=O)=O)CC7=CC=CC=C7)=O)=O)CC(O)=O)=O)=O)CC8=CN=CN8)=O)=O)=O)=O.OC(C(F)(F)F)=O
分子式C141H211N43O41•XCF3COOH
分子量3164.4
溶解度1mg/mL in water
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Galanin is a neuropeptide with diverse biological activities. [1][2][3][4][5] It binds to rat galanin (GAL) receptor subtypes GAL1-3 (IC50s = 0.339, 1.35, and 3.31 nM, respectively) and human GAL1-3 (IC50s = 0.288, 1.62, and 12.3 nM, respectively). [1] Galanin binds to and inhibits contraction of guinea pig gastric smooth muscle cells induced by carbachol . [2] In vivo, Galanin (6 nmol, i.c.v.) increases feeding behavior in rats and increases latency to hindpaw withdrawal in response to heat and mechanical stimulation in a rat model of carrageenin-induced inflammation when administered at a dose of 2 nmol injected into the nucleus accumbens.[3][4] Galanin (5 μg, i.c.v.) also inhibits acetylcholine release induced by scopolamine in the ventral hippocampus of freely moving rats. [5]

Reference:
[1]. Branchek, T.A., Smith, K.E., Gerald, C., et al. Galanin receptor subtypes. Trends Pharamacol. Sci. 21(3), 109-117 (2000).
[2]. Gu, Z.F., Pradhan, T.K., Coy, D.H., et al. Interaction of galanin fragments with galanin receptors on isolated smooth muscle cells from guinea pig stomach: Identification of a novel galanin receptor subtype. J. Pharmacol. Exp. Ther. 272(1), 371-378 (1995).
[3]. Crawley, J.N., Austin, M.C., Fiske, S.M., et al. Activity of centrally administered galanin fragments on stimulation of feeding behavior and on galanin receptor binding in the rat hypothalamus. J. Neurosci. 10(11), 3695-3700 (1990).
[4]. Yang, Y., Zhang, Y., Li, X.H., et al. Involvements of galanin and its receptors in antinociception in nucleus accumbens of rats with inflammatory pain. Neurosci. Res. 97, 20-25 (2015).
[5]. Taber, M.T., and Crawley, J.N. Galanin attenuates the effects of scopolamine but not exposure to a novel environment on acetylcholine release in the rat ventral hippocampus. Psychobiol. 27(1), 57-62 (1999).