CAS NO: | 108068-98-0 |
包装 | 价格(元) |
50 μg | 电议 |
100 μg | 电议 |
生物活性 | KT5720 is a potent, cell-permeable, specific, reversible and ATP-competitivePKAinhibitor (IC50=3.3 μM). KT5720 is effective in reversing MDR1-mediated multidrug resistance. KT5720 also reduces the excitability of dorsal root ganglion (DRG) neurons by attenuating Hyperpolarization-activated cyclic nucleotide-gated (HCN) channel activity and reducing intracellular Ca2+concentrations. KT5720 can be used in the study of haematological malignancies as well as HCN and DRG neuron-related diseases[1][2][3]. | ||||||||||||||||
IC50& Target | IC50: 11 nM (PHK); 300 nM (PDK1); 3.3 μM (PKA)[3]. | ||||||||||||||||
体外研究 (In Vitro) | KT5720 (0-8 μM; 72 h) reverses multidrug resistance in an MDR1 lymphoma cell model[1]. Cell Viability Assay[1]
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体内研究 (In Vivo) | KT5720 (5 mg/kg; i.p.; single daily for 8 days) reverses completely DNR resistance in MDR1 transgenic mice model[1].
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分子量 | 537.61 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C32H31N3O5 | ||||||||||||||||
CAS 号 | 108068-98-0 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: Methanol : 5 mg/mL(9.30 mM;Need ultrasonic and warming) 配制储备液
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