Itraconazole-d5 (R51211-d5) is the deuterium labeled Itraconazole. Itraconazole (R51211) is a triazole antifungal agent and a potent and orally activeHedgehog(Hh) signaling pathwayantagonist with anIC₅₀of ~800 nM. Itraconazole potently inhibits lanosterol14α-demethylase(cytochrome P450enzyme), thereby inhibits the oxidative conversion of lanosterol to ergosterol. Itraconazole has anticancer and antiangiogenic effects^[1][2][3].

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

710.66

C₃₅H₃₃D₅Cl₂N₈O₄

1217510-38-7

伊曲康唑 d5

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.