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Insulin degludec
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
CAS NO:844439-96-9
包装与价格：
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议
200mg电议

产品介绍
Insulin degludec 是一种超长效形式的胰岛素，用于治疗 1 型和 2 型糖尿病引起的高血糖。Insulin degludec 结合胰岛素受体的IC50值为 19.59 nM/L。Insulin degludec 可用于 1 型和 2 型糖尿病的研究。
生物活性

Insulindegludec is an ultra-long-acting form ofinsulinused for the treatment of hyperglycemia caused by type 1 and type 2 dabetes.Insulindegludec shows binding efficiency with anIC50value of 19.59 nM/L forinsulin receptor.Insulindegludec can be used for the research of type 1 and type 2 diabetes[1][2].

IC50& Target

IC50: 19.59 nM/L (insulin receptor)[2]

体外研究
(In Vitro)

Insulin degludec (0.001-1000 nM; 12 h) binds with insulin receptor with an IC50value of 19.59 nM/L[2].
Insulin degludec (200 nM; 10 min) increases glucose uptake in HL-1 cells[2].

Western Blot Analysis[2]

Cell Line:HL-1 cardiomyocytes
Concentration:200 nM
Incubation Time:0-60 min
Result:Decreased the level of Akt phosphorylation after 5 and 10 min treatment.
体内研究
(In Vivo)

Insulin degludec (5 U/kg; s.c. once daily for 30 days) affects glucose homeostasis and liver metabolism in diabetic mice undergoing insulin-induced hypoglycemia[1].

Animal Model:Male Swiss mice with diabetes[1]
Dosage:5 U/kg
Administration:Subcutaneous injection; 5 U/kg once daily for 30 days
Result:Showed a fast response to insulin-induced hypoglycemia with a glycemic level at or slightly under 100 mg/dl after 60 min and this response effect can be abolished by cortisol. Diminished rates of glucose production and showed a low lactate production in livers. Increased the number of hepatocytes.
Clinical Trial
性状

Solid

CAS 号

844439-96-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture and light, under nitrogen

Powder-80°C2 years
-20°C1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)