Harmine Hydrochloride (Telepathine Hydrochloride) is a naturalDYRKinhibitor with anticancer and anti-inflammatory activities. Harmine has a high affinity of5-HT_2Aserotonin receptor, with anK_iof 397 nM^[1].

Harmine inhibits tau phosphorylation by DYRK1A by selected DANDYs, with an IC₅₀of 190 nM^[2]. Harmine negatively regulates homologous recombination (HR) by interfering Rad51 recruitment, resulting in severe cytotoxicity in hepatoma cells. Furthermore, NHEJ inhibitor Nu7441 markedly sensitizes Hep3B cells to the anti-proliferative effects of Harmine^[3].

It is shown that brain water content is significantly increased in the TBI group. Treatment with Harmine significantly reduces the tissue water content at 1, 3 and 5 days, compared with the TBI group. Harmine treatment significantly reduces the escape latency at 3 and 5 days, compared with the TBI group. Post-TBI administration of Harmine significantly improves the motor function recovery of the rats at 1, 3 and 5 days following TBI, compared with the TBI group without Harmine treatment. The neuronal survival rate in the Harmine-treated group is significantly increased, compared with the TBI group. Administration of Harmine results in marked elevation in the expression of GLT-1, compared with the TBI group. The administration of Harmine significantly reduces the expression of caspase 3, compared with the TBI group^[4].

248.71

Solid

C₁₃H₁₃ClN₂O

343-27-1

哈尔碱盐酸盐

• Alkaloids
• Indole Alkaloids

• Plants
• Zygophyllaceae
• Peganum harmalaLinn.

Room temperature in continental US; may vary elsewhere.

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

H₂O : 10 mg/mL(40.21 mM;ultrasonic and warming and heat to 60℃)

DMSO : 5 mg/mL(20.10 mM;Need ultrasonic)

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。