CAS NO: | 857890-39-2 |
包装 | 价格(元) |
25mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
生物活性 | Lenvatinib mesylate (E7080 mesylate), an oral, multi-targeted tyrosine kinase inhibitor that inhibitsVEGFR1-3,FGFR1-4,PDGFR,KIT, andRET, shows potent antitumor activities[1][2]. | ||||||||||||||||
IC50& Target[1][2][3] |
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体外研究 (In Vitro) | Lenvatinib mesylate (E7080 mesylate) has IC50s of 4, 5.2, 22 nM for VEGFR2(KDR), VEGFR3(Flt-4), and VEGFR1/Flt-1, respectively. Lenvatinib inhibits PDGFRα, PDGFRβ, FGFR1, and KIT with IC50s of 51, 39, 46, 100 nM, respectively[3]. | ||||||||||||||||
体内研究 (In Vivo) | Lenvatinib mesylate (E7080 mesylate) (100 mg/kg, p.o.) is administeredand bevacizumab significantly inhibits local tumor growth at the m.f.p., and at the end of treatment, Lenvatinib mesylate also significantly inhibits metastasis to both regional lymph nodes and distant lung[3]. | ||||||||||||||||
Clinical Trial | |||||||||||||||||
分子量 | 522.96 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C22H23ClN4O7S | ||||||||||||||||
CAS 号 | 857890-39-2 | ||||||||||||||||
中文名称 | 乐伐替尼甲酸盐;仑伐替尼甲酸盐;乐法替尼甲酸盐 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 | 4°C, sealed storage, away from moisture and light *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light) | ||||||||||||||||
溶解性数据 | In Vitro: DMSO : 7.35 mg/mL(14.05 mM;Need ultrasonic) 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |