NG 012，神经生长因子 (NGF) 增强剂，是从疣状青霉 F-4542 的培养液中分离得到的。 NG 012 可增强 NGF 在大鼠嗜铬细胞瘤细胞系 (PC12) 中诱导的神经突生长。
| Cas No. | 141731-76-2 |
| Canonical SMILES | OC(C=C1O)=CC(C[C@@H](C)OC(C[C@@H](C)OC(C2=C(O)C=C(O)C=C2C[C@@H](C)OC(C[C@@H](CO)OC(C[C@@H](C)O3)=O)=O)=O)=O)=C1C3=O |
| 分子式 | C32H38O15 |
| 分子量 | 662.6 |
| 溶解度 | Chloroform: Soluble,Ethanol: Soluble,Methanol: Soluble |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | NG 012 is a fungal metabolite originally isolated from P. verruculosum that has fungicidal and nerve growth factor-potentiating properties. It inhibits the growth of the plant pathogenic fungi B. cinerea, P. teres, P. lingam, S. sclerotiorum, and M. fructigena in vitro. NG 012 (50 μM) increases the efficacy of the antifungal miconazole against C. albicans, reducing the IC50 value from 19.2 to 2.5 μM. It also potentiates neurite outgrowth induced by nerve growth factor (NGF) in PC12 cells in a concentration-dependent manner. |
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