CAS NO: | 1860875-51-9 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
生物活性 | Eragidomide (CC-90009) is a first-in-class GSPT1-selectivecereblon(CRBN)E3 ligase modulator, acts as a molecular glue. Eragidomide coopts the CRL4CRBNto selectively target GSPT1 for ubiquitination and proteasomal degradation[1][2]. | ||||||||||||||||
IC50& Target[1] |
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体外研究 (In Vitro) | Depletion of GSPT1 by Eragidomide rapidly induces acute myeloid leukemia (AML) apoptosis, reducing leukemia engraftment and leukemia stem cells (LSCs) in large-scale primary patient xenografting of 35 independent AML samples. Eragidomide activity is mediated by multiple layers of signaling networks and pathways within AML blasts and LSCs[1]. | ||||||||||||||||
Clinical Trial | |||||||||||||||||
分子量 | 461.85 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C22H18ClF2N3O4 | ||||||||||||||||
CAS 号 | 1860875-51-9 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 100 mg/mL(216.52 mM;Need ultrasonic) 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo: 请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用;
以下溶剂前显示的百
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