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BpV(HOpic)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
BpV(HOpic)图片
CAS NO:722494-26-0
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议

产品介绍
BpV(HOpic) 是一种有效的和选择性的PTEN抑制剂,IC50值为 14 nM。Nanocarrier-BpV(HOpic) 具有神经保护作用。
生物活性

BpV(HOpic) is a potent and selective inhibitor ofPTENwith anIC50of 14 nM. Nanocarrier-BpV(HOpic) has neuroprotective activity[1][2].

IC50& Target

IC50: 14 nM (PTEN)[1]

体外研究
(In Vitro)

BpV(HOpic) (1 μM) treatment increases cell proliferation and decreases apoptotic rate in MG63 cells received Cisplatin treatment[3].
Bpv(HOpic) (1 μM) enhances migration of C2C12 myoblasts and is associated with activation of PI3K/AKT and MAPK/ERK signalling pathways[4].
BpV(HOpic) (1 μM; 48 hours) promotes the initiation of swine follicle growth and development, similar as in rodent species and humans[5].
Nanocarrier-BpV(HOpic) enhances axonal outgrowth of neurons[2].

体内研究
(In Vivo)

BpV(HOpic) (0.05 mg/kg; i.p.) at reperfusion ameliorates liver ischemia/reperfusion (I/R) injury in vivo[6].
BpV(HOpic) (200 μg/kg; i.p.) exacerbates renal dysfunction and promotes tubular damage in mice with ischemia/reperfusion injury (IRI)[7].

Animal Model:Male Wistar rats are subjected to partial hepatic ischemia[6]
Dosage:0.05 mg/kg
Administration:I.p. injections at the start of reperfusion
Result:Ameliorated reoxygenation injury and reproduced the hepatoprotective effects obtained by adenosine A2A receptor stimulation.
Animal Model:Male C57BL/6 mice (8-12 weeks old; 20-30 g ) are subjected to renal ischemia[7]
Dosage:200 μg/kg
Administration:I.p. injections 1 h before ischemia and then administers every 6 h after ischemia for 24 hr
Result:Raised the level of serum creatinine and blood serum urea nitrogen.
分子量

347.24

性状

Solid

Formula

C6H4K2NO8V

CAS 号

722494-26-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, sealed storage, away from moisture

*该产品在溶液状态不稳定,建议您现用现配,即刻使用。

溶解性数据
In Vitro: 

H2O : 50 mg/mL(143.99 mM;ultrasonic and warming and heat to 60℃)

DMSO : 2.89 mg/mL(8.32 mM;Need ultrasonic)

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM2.8799 mL14.3993 mL28.7985 mL
5 mM0.5760 mL2.8799 mL5.7597 mL
10 mM0.2880 mL1.4399 mL2.8799 mL
*

请根据产品在不同溶剂中的溶解度,选择合适的溶剂配制储备液;该产品在溶液状态不稳定,建议您现用现配,即刻使用