BpV(HOpic) 是一种有效的和选择性的PTEN抑制剂,IC50值为 14 nM。Nanocarrier-BpV(HOpic) 具有神经保护作用。
生物活性 | BpV(HOpic) is a potent and selective inhibitor ofPTENwith anIC50of 14 nM. Nanocarrier-BpV(HOpic) has neuroprotective activity[1][2]. |
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体外研究 (In Vitro) | BpV(HOpic) (1 μM) treatment increases cell proliferation and decreases apoptotic rate in MG63 cells received Cisplatin treatment[3]. Bpv(HOpic) (1 μM) enhances migration of C2C12 myoblasts and is associated with activation of PI3K/AKT and MAPK/ERK signalling pathways[4]. BpV(HOpic) (1 μM; 48 hours) promotes the initiation of swine follicle growth and development, similar as in rodent species and humans[5]. Nanocarrier-BpV(HOpic) enhances axonal outgrowth of neurons[2].
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体内研究 (In Vivo) | BpV(HOpic) (0.05 mg/kg; i.p.) at reperfusion ameliorates liver ischemia/reperfusion (I/R) injury in vivo[6]. BpV(HOpic) (200 μg/kg; i.p.) exacerbates renal dysfunction and promotes tubular damage in mice with ischemia/reperfusion injury (IRI)[7].
Animal Model: | Male Wistar rats are subjected to partial hepatic ischemia[6] | Dosage: | 0.05 mg/kg | Administration: | I.p. injections at the start of reperfusion | Result: | Ameliorated reoxygenation injury and reproduced the hepatoprotective effects obtained by adenosine A2A receptor stimulation. |
Animal Model: | Male C57BL/6 mice (8-12 weeks old; 20-30 g ) are subjected to renal ischemia[7] | Dosage: | 200 μg/kg | Administration: | I.p. injections 1 h before ischemia and then administers every 6 h after ischemia for 24 hr | Result: | Raised the level of serum creatinine and blood serum urea nitrogen. |
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运输条件 | Room temperature in continental US; may vary elsewhere. |
储存方式 | -20°C, sealed storage, away from moisture *该产品在溶液状态不稳定,建议您现用现配,即刻使用。 |
溶解性数据 | In Vitro: H2O : 50 mg/mL(143.99 mM;ultrasonic and warming and heat to 60℃) DMSO : 2.89 mg/mL(8.32 mM;Need ultrasonic) 配制储备液 1 mM | 2.8799 mL | 14.3993 mL | 28.7985 mL | 5 mM | 0.5760 mL | 2.8799 mL | 5.7597 mL | 10 mM | 0.2880 mL | 1.4399 mL | 2.8799 mL |
*请根据产品在不同溶剂中的溶解度,选择合适的溶剂配制储备液;该产品在溶液状态不稳定,建议您现用现配,即刻使用。 |