PI4KIIIbeta-IN-11

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PI4KIIIbeta-IN-11

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2365241-79-6

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

PI4KIIIbeta-IN-11 是PI4KIIIβ抑制剂，平均 pIC₅₀为 9.1。PI4KIIIβ在 RNA 病毒和恶性疟原虫引起的疾病研究中具有重要作用。

生物活性

PI4KIIIbeta-IN-11 is an inhibitor ofPI4KIIIβ, with a mean pIC₅₀value of at least 9.1.PI4KIIIβplays a key role in diseases research of RNA viruses andPlasmodiumfalciparum^[1]^[2].

IC₅₀& Target

PI4KIIIβ

9.1 (pIC₅₀)

体外研究
(In Vitro)

PI4KIIIβ may be a relevant target protein for inhibition of Hedgehog signaling, and regulates trafficking from the Golgi system to the plasma membrane^[1].
PI4KIIIbeta-IN-11 (compound 22) (0.5 μM; 0-45 min) shows metabolic stability in human microsomes, with the intrinsic clearance of 33.7 mL/min/g^[2].

体内研究
(In Vivo)

PI4KIIIbeta-IN-11 (compound 22) (1 mg/kg; i.v.; last over 1 h) displays a low spleen concentration in rats^[2].

Animal Model:	Male Wistar Han Rats^[2]
Dosage:	1 mg/kg
Administration:	Intravenous injection, formulated in 2% DMSO in Kleptose (aq, 10% w/v); over 1 hour; euthanised at 12 h
Result:	Showed a low concentration in spleen of 5.54 ng/g.

分子量

581.71

Formula

C₃₃H₃₉N₇O₃

CAS 号

2365241-79-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.