LDHA/PDKs-IN-1 (compound 20e) is a potent and dual inhibitor of PDKs and LDHA withIC₅₀s of 0.8 and 0.15 μM, respectively. LDHA/PDKs-IN-1 reduces A549 cell proliferation with anEC₅₀of 13.2 μM and decreases the lactate formation, and increases oxygen consumption. LDHA/PDKs-IN-1 has the potential for the research ofcancerdiseases^[1].

360.38

C₁₉H₂₁FN₂O₄

2490699-40-4

Room temperature in continental US; may vary elsewhere.

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