Lutein (Xanthophyll) 是一种类胡萝卜素，具有抗炎作用。Lutein 具有多种有益作用，尤其是对眼睛健康。Lutein 通过影响活性氧 (ROS) 发挥抗炎、抗氧化酶、抗凋亡 (apoptosis) 等生物活性。Lutein 能够到达大脑，显示出抗抑郁类和神经保护作用。Lutein 具有口服活性。
| 生物活性 | Lutein (Xanthophyll) is a carotenoid with reported anti-inflammatory properties. A large body of evidence shows that lutein has several beneficial effects, especially on eye health[1]. Lutein exerts its biological activities, including anti-inflammation, anti-oxidase and anti-apoptosis, through effects onreactive oxygen species(ROS)[2][3]. Lutein is able to arrive in the brain and shows antidepressant-like and neuroprotective effects. Lutein is orally active[4]. |
体外研究
(In Vitro) | Lutein (100 or 200 μM) protects against A2-PE (a bis-retinoid compound that is the immediate precursor of the lipofuscin fluorophore A2E) photooxidation and reduces A2E photooxidation[2].
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体内研究
(In Vivo) | Lutein (40-160 mg/kg; in diet for 5 weeks) protects against severe traumatic brain injury through anti-inflammation and anti-oxidative effects via ICAM-1/Nrf-2 in rats[3].
Lutein (0.1-10 mg/kg; p.o.; once or daily for 7 and 21 days) preventsCorticosterone(HY-B1618)-induced depressive-like behavior in mice with the involvement of antioxidant and neuroprotective activities[4].
| Animal Model: | Sprague-Dawley rats, severe traumatic brain injury (STBI) model[3] | | Dosage: | 40, 80 and 160 mg/kg | | Administration: | In diet for 5 weeks | | Result: | Suppressed, interleukin (IL)-1β, IL-6 and monocyte chemoattractant protein-1 expression, reduced serum ROS levels, and reduced superoxide dismutase and glutathione peroxidase activities. Effectively downregulated the expression of NF-κB p65 and cyclooxygenase-2, intercellular adhesion molecule (ICAM)-1 protein, and upregulated nuclear factor erythroid 2 like 2 (Nrf-2) and endothelin-1 protein levels. |
| Animal Model: | Male Swiss mice, chronicCorticosterone(HY-B1618) model of depression[4] | | Dosage: | 0.1, 1 and 10 mg/kg | | Administration: | Oral administration, once or daily for 7 and 21 days | | Result: | Decreased immobility time at the dose 10 mg/kg. Counteracted the behavioral changes displayed byCorticosterone(HY-B1618) showing antidepressant-like effect. Presented antioxidant effect in the hippocampus, prefrontal cortex and plasma of mice, and exhibited a capability to protect hippocampal and prefrontal cortex slices against glutamatergic toxicity. |
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | 4°C, stored under nitrogen *In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen) |
| 溶解性数据 | In Vitro: DMSO : 25 mg/mL(43.95 mM;Need ultrasonic) 配制储备液 | 1 mM | 1.7579 mL | 8.7894 mL | 17.5787 mL | | 5 mM | 0.3516 mL | 1.7579 mL | 3.5157 mL | | 10 mM | 0.1758 mL | 0.8789 mL | 1.7579 mL |
*请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (stored under nitrogen)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。 |
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