CAS NO: | 64224-21-1 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
10mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
1 g | 电议 |
5 g | 电议 |
生物活性 | Oltipraz has an inhibitory effect onHIF-1αactivation in a time-dependent manner, completely abrogatingHIF-1αinduction at ≥10 μM concentrations, theIC50of Oltipraz forHIF-1αinhibition is 10 μM. Oltipraz is a potentNrf2activator. | ||||||||||||||||
IC50& Target | IC50: 10 μM (HIF-1α)[1]; | ||||||||||||||||
体外研究 (In Vitro) | Oltipraz inhibits HIF-1α activity and HIF-1α-dependent tumor growth, which may result from a decrease in HIF-1α stability through S6K1 inhibition in combination with an H2O2-scavenging effect. Oltipraz treatment also inhibits HIF-1α activation stimulated by either hypoxia or CoCl2. Oltipraz is a cancer chemopreventive agent and has an inhibitory effect on angiogenesis and tumor growth. [1] Oltipraz is also a competitive inhibitor of this cytochrome P450, with an apparent Ki of 10 μM. [2] | ||||||||||||||||
体内研究 (In Vivo) | In wild-type mice, hepatic levels of mRNA for all of the genes analyzed were significantly increased after Oltipraz treatment, with the highest increase (treated/control) for NQO1 mRNA levels (7.6-fold). The Northern blot analyses demonstrated that the observed increases in GST and NQO1 activities by Oltipraz in wild-type mice were preceded by significant elevations in RNA expression. Interestingly, mRNA levels of Nrf2 itself were increased more than 3-fold by Oltipraz treatment. [2] | ||||||||||||||||
Clinical Trial | |||||||||||||||||
分子量 | 226.34 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C8H6N2S3 | ||||||||||||||||
CAS 号 | 64224-21-1 | ||||||||||||||||
中文名称 | 吡噻硫酮;奥替普拉 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 6 mg/mL(26.51 mM;Need ultrasonic and warming) 配制储备液
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