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Rovanersen
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAS NO:2072901-32-5
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议
100mg电议

产品名称
WVE-120101
产品介绍
Rovanersen (WVE-120101) 是一种反义寡核苷酸,通过特异靶向 huntingtin (HTT) 基因的突变mRNA拷贝,而不影响正常的 HTT基因的mRNA,从而防止有缺陷的 huntingtin 蛋白的产生。Rovanersen 可用于亨廷顿病的研究。
生物活性

Rovanersen (WVE-120101) is an antisense oligonucleotide that specifically targets mutated mRNA copies of the huntington (HTT) gene without affecting healthy mRNA of HTT gene, thereby preventing the production of faultyHuntingtinprotein. Rovanersen can be used for huntington’s disease research[1].

体外研究
(In Vitro)

In vitro, Rovanersen (WVE-120101) leads to the selective RNase H cleavage of mutant Huntingtin allele (mHTT) over wtHTT, with no complement activation. Rovanersen selectively decreases mHTT mRNA and protein levels compared with wtHTT in multiple cells lines[1].

体内研究
(In Vivo)

In non-human primates (NHPs), Rovanersen (WVE-120101) is found in nuclear and perinuclear compartments of neurons in brain areas believed to be involved in HD pathology[1].

Clinical Trial
分子量

6617.00

性状

Solid

CAS 号

2072901-32-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)