D-threo-PDMP is a potent glucoceramide synthase (GCS) inhibitor, which reduces the glycosphingolipids on the cell surface by inhibiting glycosylation, reduces the total length of the axon plexus and the number of axon branch points, and inhibits neurite growth^[1][2].

D-threo-PDMP 预处理肝细胞可消除 TNF-α（280 ng/mL）对糖磷脂水平的刺激并增强神经酰胺的产生^[1]。
D-threo-PDMP（20μM，48小时）明显刺激系膜肾小球系膜细胞（GMC）的增殖，这些增殖被外源神经节苷脂混合物（0.1-0.2 mg/mL）或 GM3（20-100 μM）以剂量依赖的方式明显减弱。它还诱发了神经节苷脂表达的明显减少^[2]。

390.56

C₂₃H₃₈N₂O₃

109836-82-0

Room temperature in continental US; may vary elsewhere.

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