FAAH-IN-7 is a reversible and potentFAAHinhibitor with anIC₅₀value of 8.29 nM. FAAH-IN-7 suppresses oxidative stress in 1321N1 astrocytes and exhibits notable neuroprotective effect in ex vivo neuroinflammation model^[1].

FAAH-IN-7 (化合物 4e) (10 nM-30 μM; 24 h) 小鼠成纤维细胞NIH3T3和人星形胶质细胞1321N1无细胞毒性，且对K_i值为>10 μM的^[1]。
FAAH-IN-7 (10 nM, 100 nM; 30 min) 通过可逆机制抑制 FAAH。快速稀释破坏了抑制剂和酶之间的平衡，导致酶活性恢复^[1]。
FAAH-IN-7 (1 nM-1 μM; 24 h) 在 1321N1 星形胶质细胞中，从 10 nM 开始显著减少活性氧 (ROS) 的产生^[1]。

FAAH-IN-7 (化合物 4e) 在大鼠海马外植体炎症诱导的神经退变体外培养中显示抗炎作用^[1]。

447.53

C₂₆H₂₉N₃O₄

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