Epiberberine is an alkaloid isolated fromCoptis chinensis, acts as a potentAChEandBChEinhibitor, and a non-competitiveBACE1inhibitor, withIC₅₀s of 1.07, 6.03 and 8.55 μM, respectively. Epiberberine has antioxidant activity, with peroxynitrite ONOO^-scavenging effect (IC₅₀, 16.83 μM), and can be used for the research of Alzheimer disease^[1]. Epiberberine inhibits the early stage of differentiation of 3T3-L1 preadipocytes, downregulates the Raf/MEK1/2/ERK1/2 and AMPKα/Akt pathways^[2]. Epiberberinecan be used for the research of diabetic disease^[3].

Epiberberine (0, 12.5, 25, or 50 μM) dose-dependently inhibits cellular triglyceride accumulation in 3T3-L1 adipocytes, with an IC₅₀of 52.8 μM^[2].
Epiberberine (12.5-50 μM) suppresses the Raf/MEK1/ERK1/2 and AMPKα/Akt pathways in the early stage of 3T3-L1 adipocyte differentiation^[2].
Epiberberine (0.2, 1, 5 μg/mL) inhibits glucose uptake in HepG2 cells in a concentration-dependent manner^[3].

Epiberberine (225 mg/kg, p.o. daily for 40 days) reduces body weight, food consumption, water intake, and urinary output of KK-Ay mice^[3].

336.36

Solid

C₂₀H₁₈NO₄⁺

6873-09-2

表小檗碱

• Alkaloids
• Isoquinoline Alkaloids

• Plants
• Ranunculaceae
• Coptis chinensisFranch.

Room temperature in continental US; may vary elsewhere.

DMSO : 3.33 mg/mL(9.90 mM;ultrasonic and warming and heat to 60℃)

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