Tolcapone-d4 (Ro 40-7592-d4) is the deuterium labeled Tolcapone. Tolcapone (Ro 40-7592) is a selective, orally active and powerful mixed (peripheral and central)COMTinhibitor with anIC₅₀of 773 nM in the liver^[1]. Tolcapone is also a potent inhibitor of α-syn and Aβ42 oligomerization and fibrillogenesis^[2]. Tolcapone induces oxidative stress leading toapoptosisand inhibition of tumor growth in neuroblastoma^[3].

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

277.27

C₁₄H₇D₄NO₅

1246816-93-2

托卡朋 d4

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.