CAS NO: | 2133294-96-7 |
包装 | 价格(元) |
10mM (in 1mL DMSO) | 电议 |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
50mg | 电议 |
100mg | 电议 |
Cas No. | 2133294-96-7 |
别名 | PXT002331 (monohydrochloride) |
Canonical SMILES | O/N=C1C=C(C2=NC=C(C=CS3)C3=C2)OC4=C\1C=CC(CCCN5CCOCC5)=C4.Cl |
分子式 | C23H24ClN3O3S |
分子量 | 457.97 |
溶解度 | DMSO : 5 mg/mL (10.92 mM) |
储存条件 | Store at -20°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
产品描述 | Foliglurax monohydrochloride (PXT002331 monohydrochloride) is a highly selective and potent, brain-penetrant mGluR4 positive allosteric modulator (PAM), with an EC50 of 79±19 nM[1]. Antiparkinsonian effect[1]. Foliglurax, a highly selective and potent mGlu4 receptor PAM with a marked brain-penetrance feature, might revolutionize the field of mGlu4 receptor drug targeting in CNS disorders[2]. [1]. Charvin D, et al. Discovery, Structure-Activity Relationship, and Antiparkinsonian Effect of a Potent and Brain-Penetrant Chemical Series of Positive Allosteric Modulators of Metabotropic Glutamate Receptor 4. J Med Chem. 2017 Oct 26;60(20):8515-8537. [2]. Volpi C, et al. Opportunities and challenges in drug discovery targeting metabotropic glutamate receptor 4. Expert Opin Drug Discov. 2018 May;13(5):411-423. |