Chlorotetracycline (7-Chlorotetracycline) 是一种特异性强的钙离子载体抗生素，可抑制氨酰-tRNA 与核糖体的结合。
| Cas No. | 57-62-5 |
| 别名 | 氯四环素; 7-Chlorotetracycline |
| Canonical SMILES | OC([C@@](C(C(C(N)=O)=C(O)[C@H]1N(C)C)=O)(O)[C@@]1([H])C2)=C([C@@]2([H])[C@@]3(O)C)C(C4=C3C(Cl)=CC=C4O)=O |
| 分子式 | C22H23ClN2O8 |
| 分子量 | 478.9 |
| 溶解度 | DMF: Soluble,DMSO: Soluble,Ethanol: Soluble,Methanol: Soluble |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Chlortetracycline is a broad-spectrum antibiotic originally isolated from S. aureofaciens. It inhibits growth of both Gram-positive and Gram-negative bacteria at a range of 0.1-100 μg/ml against A. aerogenes, D. pneumoniae, E. coli, K. pneumoniae, P. morganii, and several species of Haemophilus, Neisseria, Salmonella, and Staphylococcus. Chlortetracycline protects mice from infection by various strains of S. aureus with protective doses (PD50s) of 0.2-7.5 mg/kg, and from infection by E. coli (PD50 = 3 mg/kg) and K. pneumoniae (PD50 = 75 mg/kg). It acts by inhibiting protein synthesis, and it binds to a single site on the 30S ribosome subunit. Chlortetracycline is an ionophore and is selective for calcium over sodium, potassium, magnesium, strontium, and barium. It transports calcium from an aqueous phase into an organic phase environment or into multilamellar vesicles. Chlortetracycline is also a fluorescent dye that can be used to monitor calcium flux. |
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