Acivicin (AT-125) 是一种由 Streptomyces sviceus 生产的天然产物，是一种 γ-谷氨酰转肽酶 (GGT) 抑制剂。
| Cas No. | 42228-92-2 |
| 别名 | 异恶唑醋酸 |
| Canonical SMILES | ClC1=NO[C@@]([C@H](N)C(O)=O)([H])C1 |
| 分子式 | C5H7ClN2O3 |
| 分子量 | 178.6 |
| 溶解度 | PBS (pH 7.2): 1.4 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Acivicin is a glutamine analog that irreversibly inhibits glutamine-dependent amidotransferases involved in nucleotide and amino acid biosynthesis (Kis = 10 and 560 μM for anthranilate synthase and glutamate synthase, respectively). It also reversibly inhibits γ-glutamyl transpeptidase. Acividin has been used to elucidate aspects of glutathione metabolism and has known anti-tumorigenic activity. |
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