KBC-007 is a synthetic branched chain-containing analog of α-galactosylceramide (α-GalCer).
| Cas No. | 1037297-61-2 |
| Canonical SMILES | OC[C@@H]1[C@H](O)[C@H](O)[C@@H](O)[C@@H](OC[C@@H]([C@H](O)[C@H](O)CCCCCCCCCCCCCC)NC(CCCCCCCN(CCCCCCC)CCCCCCC)=O)O1 |
| 分子式 | C46H92N2O9 |
| 分子量 | 817.2 |
| 溶解度 | DMSO: 20 mg/ml,Ethanol: 12 mg/ml,Water: 18 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | KBC-007 is a synthetic branched chain-containing analog of α-galactosylceramide (α-GalCer). It induces IL-4 and IFN-γ secretion by mouse splenocytes when used at a concentration of 0.5 ng/ml and IL-2 secretion by DN32.D3 NKT hybridoma cells co-cultured with CD1d-transfected RBL cells pre-loaded with KBC-007 at a concentration of 8 ng/ml. KBC-007 (1 μg per animal) increases levels of IL-4, but not IFN-γ, to a similar degree as α-GalCer in mouse serum. KBC-007 (0.5 μg per animal) increases the survival rate of mice immunized with the inactivated influenza A virus A/PR/8/34 in a model of influenza infection. |
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