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hMAO-B/MB-COMT-IN-2
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
hMAO-B/MB-COMT-IN-2图片
包装与价格：
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
hMAO-B/MB-COMT-IN-2 是一种双重的MAO-B/MB-COMT抑制剂 (IC50s: hMAO-B 为 2.5 μM，MB-COMT 为 3.84 μM)。hMAO-B/MB-COMT-IN-2 可保护细胞免受氧化损伤。hMAO-B/MB-COMT-IN-2 可用于帕金森病 (PD) 等神经退行性疾病的研究。
生物活性

hMAO-B/MB-COMT-IN-2 is a dualMAO-B/MB-COMTinhibitor (IC50s: 4.27 μΜ for hMAO-B, 2.69 μΜ for MB-COMT). hMAO-B/MB-COMT-IN-2 protects cells against oxidative damage. hMAO-B/MB-COMT-IN-2 can be used in the research of neurodegeneration disease, such as Parkinson’s Disease (PD)[1].

体外研究
(In Vitro)

hMAO-B/MB-COMT-IN-2 (compound 8, 50 μM, 24 h) decreases in resazurin reduction in differentiated SH-SY5Y cells[1].
hMAO-B/MB-COMT-IN-2 (50 μM, 24 h) displays lysosomal toxicity by producing ROS in differentiated SH-SY5Y cells[1].
hMAO-B/MB-COMT-IN-2 (10 μM, 30 min) displays remarkable cytoprotective effects against t-BHP in differentiated SH-SY5Y cells[1].
hMAO-B/MB-COMT-IN-2 is predicted to cross the blood-brain barrier (BBB) by passive diffusion, determined by the parallel artificial membrane permeability assay (PAMPA)-BBB kit[1].
hMAO-B/MB-COMT-IN-2 (30-50 μM, 24 h) has good safety profile in SK-N-SH cells[1].

分子量

298.34

Formula

C17H18N2O3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.