Cathepsin K inhibitor3 (compound 23) is a highly selectivecathepsin Kinhibitor with anIC₅₀value of 0.5 nM.Cathepsin K inhibitor3 has a favorable pharmacokinetic profile and may be used in osteoarthritis (OA) disease studies^[1].

Cathepsin K inhibitor 3 (compound 23) (p.o., 0.03-15 mg/kg, daily, 4 days) results in a significant and dose-dependent reduction in uCTX-I, with an 81% reduction in uCTX-1 levels at 0.3 mg/kg and a slightly more complete reduction at 15 mg/kg in dog^[1].
The pharmacokinetic parameters of compound 23

562.65

C₃₀H₃₁FN₄O₄S

1694638-70-4

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