Leupeptin is a broad-spectrum, membrane-permeableprotease inhibitor. Leupeptin potently inhibitsserine,cysteineandthreonine proteases. Leupeptin inhibitsM^pro(the mainproteaseofSARS-CoV-2) and also has anti-inflammatory activity^[1][2][3].

Cathepsin B, Cathepsin H, Cathepsin L, Ser/Thr Protease, Mpro^[1][2][3].

Leupeptin (0.06-200 μM; 72 h) 显著抑制 Vero 细胞中 SARS-CoV-2 病毒 RNA (vRNA) 的拷贝数^[1]。
Leupeptin 抑制 Vero 细胞中 SARS-CoV-2 的 RNA 水平，EC₅₀值为 42.34 μM^[1]。
Leupeptin 对 M^pro有一定的抑制活性，其 IC₅₀值为127.2 μM^[1]。
Leupeptin 对人类冠状病毒 229E 株的 IC₅₀值为 0.4 μg/mL (约 1 μM)^[1]。

Leupeptin (0, 9, 18, 36 mg/kg; i.p.; single) is well tolerated by the animals and produces a strong, dose-dependent increase in LC3b-II in both the total tissue extracts and the lysosome and autophagosome-enriched pellet fraction^[2].

426.55

C₂₀H₃₈N₆O₄

55123-66-5

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.