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5-hydroxy Omeprazole
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
5-hydroxy Omeprazole图片
CAS NO:92340-57-3
包装与价格：
包装价格(元)
500μg电议
1mg电议

产品介绍

5-hydroxy Omeprazole is a major metabolite of omeprazole, an inhibitor of the gastric H+/K+-ATPase pump.

Cas No.92340-57-3
别名5-羟基奥美拉唑
化学名4-methoxy-6-[[(6-methoxy-1H-benzimidazol-2-yl)sulfinyl]methyl]-5-methyl-3-pyridinemethanol
Canonical SMILESCOC1=CC=C2C(N=C(S(CC3=C(C)C(OC)=C(CO)C=N3)=O)N2[H])=C1
分子式C17H19N3O4S
分子量361.4
溶解度10mg/mL in DMSO, 20mg/mL in DMF, 2mg/mL in Ethanol
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

5-hydroxy Omeprazole is a major metabolite of omeprazole , an inhibitor of the gastric H+/K+-ATPase pump.[1] 5-hydroxy Omeprazole is produced from omeprazole by the action of cytochrome P450 (CYP) isoform 2C19, a monooxygenase. [2][3] CYP2C19 polymorphisms significantly influence the metabolism of omeprazole, and individuals may be classified as homozygous extensive metabolizers, heterozygous extensive metabolizers, and poor metabolizers.[1]

Reference:
[1]. Shi, S., and Klotz, U. Proton pump inhibitors: An update of their clinical use and pharmacokinetics. Eur. J. Clin. Pharmacol. 64(10), 935-951 (2008).
[2]. Abelo, A., Andersson, T.B., Antonsson, M., et al. Stereoselective metabolism of omeprazole by human cytochrome P450 enzymes. Drug Metab. Dispos. 28(8), 966-972 (2000).
[3]. Karam, W.G., Goldstein, J.A., Lasker, J.M., et al. Human CYP2C19 is a major omeprazole 5-hydroxylase, as demonstrated with recombinant cytochrome P450 enzymes. Drug Metab. Dispos. 24, 1081-1087 (1996).