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Hydroxycitric acid tripotassium hydrate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Hydroxycitric acid tripotassium hydrate图片
CAS NO:6100-05-6
包装与价格:
包装价格(元)
10 mM * 1 mL in Water电议
500mg电议
1 g电议
5 g电议

产品名称
三水合钾柠檬酸
Potassium citrate monohydrate
产品介绍
Hydroxycitric acid tripotassium hydrate (Potassium citrate monohydrate) 是藤黄果的主要活性成分。Hydroxycitric acid tripotassium hydrate 可竞争性抑制柠檬酸裂解酶 (ATP citrate lyase) ,并具有减肥效果。Hydroxycitric acid tripotassium hydrate 有效抑制结石形成并抑制HIF,具有抗氧化,抗炎和抗肿瘤作用。
生物活性

Hydroxycitric acid tripotassium hydrate (Potassium citrate monohydrate) is the major active ingredient ofGarcinia cambogia. Hydroxycitric acid tripotassium hydrate competitively inhibitsATP citrate lyasewith weight loss benefits. Hydroxycitric acid tripotassium hydrate effective inhibits stones formation and also inhibitsHIF, and has antioxidation, anti-inflammation and anti-tumor effects[1][2][3][4].

IC50& Target

Human Endogenous Metabolite

 

体外研究
(In Vitro)

Hydroxycitric acid shows an HIF inhibitory effect compared with the control group in ARPE19 cells and 661W cells. Hydroxycitric acid can downregulate Hif1a and the downstream genes in ARPE19 cells and 661W cells. Hydroxycitric acid suppresses HIF-1α protein expression increased by CoCl2 administration in ARPE19 cells and 661W cells[2].
In chicken hepatocytes, Hydroxycitric acid decreases the accumulation of lipid droplets and accelerated energy metabolism. Hydroxycitric acid protects the cells from ER stress by increasing the antioxidant status and mitochondrial functions[2].

体内研究
(In Vivo)

Hydroxycitric acid (100-200 mg/kg) treatment could reduce markers of renal impairment (Blood Urea Nitrogen and serum creatinine). There is significantly less calcium oxalate crystal deposition in mice (male C57BL/6J mice) treated with Hydroxycitric acid. Hydroxycitric acid attenuates the oxidative stress induced by calcium oxalate crystallization. Hydroxycitric acid has inhibitory effects on calcium oxalate-induced inflammatory cytokines, such as MCP-1, IL-1 β, and IL-6. In addition, Hydroxycitric acid alleviates tubular injury and apoptosis caused by calcium oxalate crystals[1].
The administration of Hydroxycitric acid can suppress body weight gain and fat accumulation in animals[3].

Clinical Trial
分子量

324.41

性状

Solid

Formula

C6H7K3O8

CAS 号

6100-05-6

中文名称

三水合钾柠檬酸

结构分类
  • Ketones, Aldehydes, Acids
来源
  • Plants
  • Guttiferae
  • Garcinia cambogia
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro: 

H2O : 120 mg/mL(369.90 mM;Need ultrasonic)

DMSO :< 1 mg/mL(insoluble or slightly soluble)

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM3.0825 mL15.4126 mL30.8252 mL
5 mM0.6165 mL3.0825 mL6.1650 mL
10 mM0.3083 mL1.5413 mL3.0825 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture)。-80℃ 储存时,请在 6 个月内使用,-20℃ 储存时,请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液,再依次添加助溶剂:

——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂: PBS

    Solubility: 100 mg/mL (308.25 mM); Clear solution; Need ultrasonic

*以上所有助溶剂都可在本网站选购。