CAS NO: | 6100-05-6 |
包装 | 价格(元) |
10 mM * 1 mL in Water | 电议 |
500mg | 电议 |
1 g | 电议 |
5 g | 电议 |
生物活性 | Hydroxycitric acid tripotassium hydrate (Potassium citrate monohydrate) is the major active ingredient ofGarcinia cambogia. Hydroxycitric acid tripotassium hydrate competitively inhibitsATP citrate lyasewith weight loss benefits. Hydroxycitric acid tripotassium hydrate effective inhibits stones formation and also inhibitsHIF, and has antioxidation, anti-inflammation and anti-tumor effects[1][2][3][4]. | ||||||||||||||||
IC50& Target |
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体外研究 (In Vitro) | Hydroxycitric acid shows an HIF inhibitory effect compared with the control group in ARPE19 cells and 661W cells. Hydroxycitric acid can downregulate Hif1a and the downstream genes in ARPE19 cells and 661W cells. Hydroxycitric acid suppresses HIF-1α protein expression increased by CoCl2 administration in ARPE19 cells and 661W cells[2]. | ||||||||||||||||
体内研究 (In Vivo) | Hydroxycitric acid (100-200 mg/kg) treatment could reduce markers of renal impairment (Blood Urea Nitrogen and serum creatinine). There is significantly less calcium oxalate crystal deposition in mice (male C57BL/6J mice) treated with Hydroxycitric acid. Hydroxycitric acid attenuates the oxidative stress induced by calcium oxalate crystallization. Hydroxycitric acid has inhibitory effects on calcium oxalate-induced inflammatory cytokines, such as MCP-1, IL-1 β, and IL-6. In addition, Hydroxycitric acid alleviates tubular injury and apoptosis caused by calcium oxalate crystals[1]. | ||||||||||||||||
Clinical Trial | |||||||||||||||||
分子量 | 324.41 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C6H7K3O8 | ||||||||||||||||
CAS 号 | 6100-05-6 | ||||||||||||||||
中文名称 | 三水合钾柠檬酸 | ||||||||||||||||
结构分类 |
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来源 |
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运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 | 4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) | ||||||||||||||||
溶解性数据 | In Vitro: H2O : 120 mg/mL(369.90 mM;Need ultrasonic) DMSO :< 1 mg/mL(insoluble or slightly soluble) 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo: 请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用;
以下溶剂前显示的百
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