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Regdanvimab
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAS NO:2444308-95-4
包装与价格:
包装价格(元)
1mg电议
5mg电议

产品名称
CT-P59
产品介绍
Regdanvimab (CT-P59) 是一种人单克隆抗体,靶向SARS-CoV-2刺突蛋白的受体结合域,阻断与ACE2的相互作用以防止病毒进入。Regdanvimab 可用于 COVID-19 的研究。
生物活性

Regdanvimab (CT-P59) is a human monoclonal antibody that targets the receptor-binding domain ofSARS-CoV-2spike protein, blocking interaction withACE2for viral entry. Regdanvimab can be used for the research of COVID-19[1].

IC50& Target

SARS-CoV-2, ACE2[1]

体外研究
(In Vitro)

Regdanvimab (CT-P59) (0-1000 ng/mL; 72 h) can neutralize Gamma, Delta and Epsilon variants with IC50s of 161.5-1237 ng/mL[1].

体内研究
(In Vivo)

Regdanvimab (CT-P59) (5-80 mg/kg; i.p.; single dose) 可以降低小鼠 Gamma 和 Delta 株的病毒负担[1]

Animal Model:hACE2 transgenic (TG) mice inoculated with Gamma or Delta variant[1]
Dosage:5, 20, 40, and 80 mg/kg
Administration:Intraperitoneal injection, 8 h post-inoculation, single dose
Result:Delayed body weight loss and showed a statistically significant difference compared to the placebo group. Prevented the weight loss of the mice infected with Delta variant. Significantly inhibited the virus replication in the respiratory tract.
CAS 号

2444308-95-4

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.