AKB-6899 是一种脯氨酰羟化酶结构域 3 (PHD3) 抑制剂，是一种选择性 HIF-2α 稳定剂。 AKB-6899 还增加 GM-CSF 处理的巨噬细胞产生的 VEGF 受体 (sVEGFR-1) 的可溶形式，并具有抗肿瘤和抗血管生成作用。
| Cas No. | 70763-62-1 |
| 别名 | 2-脱氧-2-氟-L-岩藻糖 |
| Canonical SMILES | C[C@H](O)[C@@H](O)[C@@H](O)[C@H](F)C=O |
| 分子式 | C6H11FO4 |
| 分子量 | 166.1 |
| 溶解度 | DMF: 20 mg/ml,DMSO: 30 mg/ml,Ethanol: 0.25 mg/ml,PBS (pH 7.2): 10 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Fucose is a deoxyhexose that is present in many organisms. Fucose-containing glycans, generated by fucosyltransferase using GDP-fucose, have roles in cell signaling, cell-cell interactions, and blood properties. 2-deoxy-2-fluoro L-Fucose is a fluorinated fucose analog. It can be metabolized inside the cell to a substrate-based inhibitor of fucosyltransferases. Alternatively, it can be converted in vitro to GDP-2-deoxy-2-fluoro L-fucose, a competitive inhibitor of α1,3-fucosyltransferase V (Ki = 4.2 µM). |
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