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Curcumenol
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Curcumenol图片
CAS NO:19431-84-6
包装与价格：
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议

产品介绍
Curcumenol ((+)-Curcumenol) 是一种有效的 CYP3A4 抑制剂，IC50 为 12.6 μM，是具有重要药用价值的姜黄属植物的成分之一，具有神经保护、抗炎、抗肿瘤和保肝活动。
Cas No.19431-84-6
别名莪术醇,(+)-Curcumenol
Canonical SMILESCC([C@@]1([H])[C@]([C@@H](C)CC1)(O2)C/3)=C[C@]2(O)C3=C(C)/C
分子式C15H22O2
分子量234.3
溶解度DMF: 10 mg/ml,DMSO: 5 mg/ml,Ethanol: 3 mg/ml,PBS (pH 7.2): 0.3 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Curcumenol ((+)-Curcumenol) is a potent CYP3A4 inhibitor with an IC50 of 12.6 μM, which is one of constituents in the plants of medicinally important genus of Curcuma zedoaria, with neuroprotection, anti-inflammatory, anti-tumor and hepatoprotective activities. Curcumenol ((+)-Curcumenol) suppresses Akt-mediated NF-κB activation and p38 MAPK signaling pathway in LPS-stimulated BV-2 microglial cells[1][2].

References:
[1]. Sun DX, et al. Inhibitory effects of curcumenol on human liver cytochrome P450 enzymes. Phytother Res. 2010 Aug;24(8):1213-6.
[2]. Lo JY, et al. Curcumenol isolated from Curcuma zedoaria suppresses Akt-mediated NF-κB activation and p38 MAPK signaling pathway in LPS-stimulated BV-2 microglial cells. Food Funct. 2015 Nov;6(11):3550-9.