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(3S)-hydroxy Quinidine
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
(3S)-hydroxy Quinidine图片
CAS NO:53467-23-5
包装与价格：
包装价格(元)
500μg电议
1mg电议

产品介绍
Cas No.53467-23-5
别名(3S)-3-羟基奎尼定
Canonical SMILESCOC1=CC=C2C(C([C@H](O)[C@@]3([H])C[C@H]4[C@](C=C)(O)C[N@@]3CC4)=CC=N2)=C1
分子式C20H24N2O3
分子量340.4
溶解度Methanol: Soluble
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

(3S)-hydroxy Quinidine is an active quinidine metabolite. Quinidine, an antiarrhythmic agent, undergoes rapid first-pass metabolism by the cytochrome P450 (CYP) isoforms CYP3A4, CYP2C9, CYP2E1, and CYP3A5, with CYP3A4 being the most active enzyme in the (3S)-hydroxy quinidine formation. (3S)-hydroxy Quinidine prolongs repolarization of canine Purkinje fibers in vitro and prevents ventricular fibrillation and ventricular tachycardia after coronary reperfusion in isolated rat hearts in a dose-dependent manner.