Leu-AMS (compound 6), a leucine analogue, is a potent inhibitor ofleucyl-tRNA synthetase(LRS) with anIC₅₀of 22.34 nM, which inhibits the catalytic activity of LRS but did not affect the leucine-inducedmTORC1activation. Leu-AMS shows cytotoxicity incancercells and normal cells, and inhibits the growth of bacteria^[1].

IC50: 22.34 nM (LRS)^[1]

Leu-AMS is proved to be a potent inhibitor of Leucyl-tRNA Synthetase (LRS) with an IC₅₀value of 22.34 nM. Leu-AMS is highly cytotoxic in both cancer cells and normal cells. Leu-AMS does not affect S6 kinase (S6K) phosphorylation at all. Leu-AMS inhibits the catalytic activity of LRS but does not affect the leucine-induced mTORC1 activation^[1].

459.48

Solid

C₁₆H₂₅N₇O₇S

288591-93-5

Room temperature in continental US; may vary elsewhere.

DMSO : ≥ 49.17 mg/mL(107.01 mM)

*"≥" means soluble, but saturation unknown.

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