AKR1C3-IN-9 is a selective inhibitor ofAldo-keto Reductase1C3 (AKR1C3)with anIC₅₀value of 8.92 nM. AKR1C3-IN-9 significantly reverses theDoxorubicin(HY-15142A) (DOX) resistance in a resistant breastcancercell line^[1].

IC50: 8.92 nM (AKR1C3)^[1]

AKR1C3-IN-9 (compound 24) (10-100 μM; 72 h and 96 h) 对 3 种乳腺癌细胞系 (MDA-MB-231、MCF-7) 均有较弱的抗增殖作用，抑制范围为 100 μM^[1]。
AKR1C3-IN-9 (10 μM, 25 μM, 50 μM; 72 h) 与 10-50 μM DOX 协同抑制 MCF-7 细胞增殖^[1]。
AKR1C3-IN-9 (10 μM; 8 d) 与 50 μM DOX 协同抑制 MCF-7/DOX 细胞系的增殖、克隆生存，从而恢复对 DOX 的敏感性^[1]。

352.38

C₂₀H₂₀N₂O₄

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.