EN40

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EN40

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2094547-67-6

包装与价格：

包装	价格(元)
5mg	电议
10mg	电议
25mg	电议
50mg	电议
100mg	电议

产品介绍

EN40 是一种有效的选择性乙醛脱氢酶 3A1 (ALDH3A1) 抑制剂，一种共价配体，IC₅₀值为 2 uM。

生物活性

EN40 is a potent, selectivealdehyde dehydrogenase3A1 (ALDH3A1)inhibitor as a covalent ligand, exhibits anIC₅₀value of 2 uM^[1]

IC₅₀& Target

IC50: 2 uM (ALDH3A1)^[1]

体外研究
(In Vitro)

EN40 (10-1000 μM; 48 hours) shows inhibitory effecton ALDH3A1 activity and impairs A549 cell survival^[1].

Cell Viability Assay^[1]

Cell Line:	A549 cells
Concentration:	10 μM; 100 μM; 1000 μM
Incubation Time:	48 hours
Result:	Inhibited A549 cells survival.

体内研究
(In Vivo)

EN40 (intraperitoneal injection; 50mg/kg; from 14 days; once per day) exerts strong anti-tumorigenic effects in established A549 tumor xenografts, shows good tolerability with no body weight loss in mice^[1].

Animal Model:	SCID mice with A549 cells^[1]
Dosage:	50 mg/kg
Administration:	Intraperitoneal injection; 50mg/kg; from 14 days; once per day
Result:	Had strong anti-tumorigenic effects in tumor xenografts.

分子量

217.26

性状

Oil

Formula

C₁₃H₁₅NO₂

CAS 号

2094547-67-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, stored under nitrogen

*该产品在溶液状态不稳定，建议您现用现配，即刻使用。

溶解性数据

In Vitro:

DMSO : 5 mg/mL(23.01 mM;Need ultrasonic)

Ethanol : 2 mg/mL(9.21 mM;Need ultrasonic)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	4.6028 mL	23.0139 mL	46.0278 mL
5 mM	0.9206 mL	4.6028 mL	9.2056 mL
10 mM	0.4603 mL	2.3014 mL	4.6028 mL

请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液；该产品在溶液状态不稳定，建议您现用现配，即刻使用。