CAS NO: | 1005334-57-5 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
生物活性 | CVT-10216 is a highly selective, reversiblealdehyde dehydrogenase-2 (ALDH-2)inhibitor with anIC50of 29 nM. CVT-10216 also has inhibitory effect of ALDH-1 with anIC50of 1.3 μM. CVT-10216 can reduce excessive alcohol drinking in alcohol-preferring rats and exhibit anxiolytic effects[1]. | ||||||||||||||||
IC50& Target | IC50: 29 nM (ALDH-2)[1] | ||||||||||||||||
体内研究 (In Vivo) | CVT-10216 (intraperitoneal injection; 3.75, 7.5, or 15 mg/kg) exhibits a increase in social interaction as a dose-dependent manner, punctuated by a 2-fold increase in social interaction after 15 mg/kg in Fawn-Hooded rats[1].CVT-10216 (intraperitoneal injection; 3.75 or 15 mg/kg) are determined 5 h into the third withdrawal.It has the anxiolytic effect of 15 mg/kg CVT-10216 in this model, but has no significant effects on locomotor activity[1]. | ||||||||||||||||
分子量 | 465.48 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C24H19NO7S | ||||||||||||||||
CAS 号 | 1005334-57-5 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMF : 25 mg/mL(53.71 mM;Need ultrasonic and warming) DMSO : 20 mg/mL(42.97 mM;Need ultrasonic and warming) 配制储备液
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