PF-06471553

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PF-06471553

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1808094-07-6

包装与价格：

包装	价格(元)
10 mM * 1 mL in DMSO	电议
5mg	电议
10mg	电议
25mg	电议
50mg	电议
100mg	电议

产品介绍

PF-06471553 是一种有效的，选择性的，可口服的monoacylglycerol acyltransferase 3 (MGAT3)抑制剂，IC₅₀值为 92 nM。

生物活性

PF-06471553 is a potent, selective and orally availablemonoacylglycerolacyltransferase3 (MGAT3)inhibitor, with anIC₅₀of 92 nM.

IC₅₀& Target

IC50: 92 nM (MGAT3)^[1]

体外研究
(In Vitro)

PF-06471553 (6f) is a potent and selective monoacylglycerol acyltransferase 3 (MGAT3) inhibitor, with an IC₅₀of 92 nM, and shows >160 fold in vitro selectivity for MGAT3 over DGAT1 (IC₅₀, >50 μM), DGAT2 (IC₅₀, >100 μM), MGAT1 (IC₅₀, 14.9 μM), and MGAT2 (IC₅₀, 19.8 μM). PF-06471553 exhibits inhibitory activity against MGAT3 in HEK-293 cells with an IC₅₀of 205 nM (pIC₅₀, 6.69)^[1].

体内研究
(In Vivo)

PF-06471553 (200 mg/kg, p.o.) in addition with (DGAT1 and DGAT2) inhibitors shows additional inhibition of glycerol-d5 incorporated triolein in hMGAT3 mice, and with no effect on WT mice^[1].

分子量

467.54

性状

Solid

Formula

C₂₃H₂₅N₅O₄S

CAS 号

1808094-07-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : ≥ 150 mg/mL(320.83 mM)

*"≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	2.1389 mL	10.6943 mL	21.3885 mL
5 mM	0.4278 mL	2.1389 mL	4.2777 mL
10 mM	0.2139 mL	1.0694 mL	2.1389 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。