hACC2-IN-1 is a potentacetyl-CoA carboxylase2(ACC2) inhibitor, with anIC₅₀value of 2.5 μM (hACC2). hACC2-IN-1 could be used for obesity research^[1].

ACC2 isoform, presents on the mitochondrial surface, inhibits carnitine palmitoyl transferase 1 (CPT-1) and converts acetyl-CoA into malonylCoA for de novo lipogenesis in the cytosol^[1].
ACCs inhibition will change cellular substrate and favour lipid oxidation, thus preventing deleterious lipids from accumulating in oxidative tissue such as muscle, heart and liver^[1].
hACC2-IN-1 shows good potency against the human ACC2 (hACC2) enzyme^[1].

432.58

C₂₃H₃₂N₂O₄S

192323-14-1

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