CAS NO: | 1353224-53-9 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
生物活性 | CMS-121 is aquinolonederivative and an orally activeacetyl-CoA carboxylase1 (ACC1)inhibitor. CMS-121 protects HT22 cells against ischemia and oxidative damage withEC50values of 7 nM and 200 nM, respectively. CMS-121 has strong neuroprotective, anti-inflammatory, antioxidative and renoprotective activities[1][2][3]. | ||||||||||||||||
IC50& Target | Acetyl-CoA carboxylase 1 (ACC1)[1] | ||||||||||||||||
体外研究 (In Vitro) | CMS-121 (1 μM; 4 hours; HT22 cells) treatment increases the phosphorylation of ACC1 at serine 79. CMS-121 can increase acetyl-CoA in cells[1]. Western Blot Analysis[1]
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体内研究 (In Vivo) | CMS-121 (~20 mg/kg; oral administration; daily; for 4 months; female SAMP8 mice) treatment reduces cognitive decline as well as metabolic and transcriptional markers of aging in the brain when administered to rapidly aging SAMP8 mice. CMS-121 preserves mitochondrial homeostasis by regulating acetyl-coenzyme A (acetyl-CoA) metabolism[1].
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Clinical Trial | |||||||||||||||||
分子量 | 321.37 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C20H19NO3 | ||||||||||||||||
CAS 号 | 1353224-53-9 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 50 mg/mL(155.58 mM;Need ultrasonic) 配制储备液
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以下溶剂前显示的百
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